TNFRSF25, also known as tumor necrosis factor receptor superfamily member 25, is a member of the TNF receptor superfamily that binds to the TNF-like protein TL1A. TNFRSF25 signals are required to exert T helper cell 2 effector function in Th2-polarized CD4 cells and co-stimulate interleukin-13 production by glycosphingolipidactivated NKT cells. Its axis is a novel immune pathway that participates in the pathogenesis of a variety of autoimmune rheumatic diseases. These molecules may be promising therapeutic targets for inflammatory arthritis. Recombinant protein corresponding to aa25-199 from human DR3/TNFRSF25, fused to hIgG-His-Tag at C-terminal, expressed in Baculovirus. Molecular Weight: ~46.1kD Biological Activity: Measured by its binding ability in a functional ELISA with Human TL1A/TNFSF15. The ED50 range 5ug/ml. Amino Acid Sequence: QGGTRSP RCDCAGDFHK KIGLFCCRGC PAGHYLKAPC TEPCGNSTCL VCPQDTFLAW ENHHNSECAR CQACDEQASQ VALENCSAVA DTRCGCKPGW FVECQVSQCV SSSPFYCQPC LDCGALHRHT RLLCSRRDTD CGTCLPGFYE HGDGCVSCPT STLGSCPERC AAVCGWRQ Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
