GSK-A1 is a potent inhibitor of PI4KA. In vitro using HEK-AT1 cells, GSK-A1 had an IC50 of about 3nM. Phosphatidylinositol 4-kinase type IIIalpha (PI4KA) is a host factor essential for hepatitis C virus replication and hence is a target for drug development. RNAi studies have shown that PI4KA is a mandatory host factor in HCV replication. Down-regulation of PI4KA appears to be reasonably tolerated by cultured cell models and results. Synonyms: 5-(2-amino-1-(4-morpholinophenyl)-1H-benzo[d]imidazol-6-yl)-N-(2-fluorophenyl)-2- methoxypyridine-3-sulfonamide CAS No: 1416334-69-4 Molecular Formula: C29H27FN6O4S Molecular Weight: 574.63 Purity: 95% Solubility: DMSO Storage: 2 years -20C, Powder 1 month, -4C in DMSO, More than one month -80C in DMSO
Molekulargewicht:
574.63
Reinheit:
95%
CAS Nummer:
[1416334-69-4]
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