CD72, Recombinant, Human, aa117-359, hIgG-His-Tag

Produktübersicht

• Artikelname: CD72, Recombinant, Human, aa117-359, hIgG-His-Tag
• Artikelnummer: USB-532278
• Hersteller Artikelnummer: 532278
• Alternativnummer: USB-532278-50,USB-532278-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

CD72, also known as B-cell differentiation antigen CD72, is a type II transmembrane glycoprotein carrying a C-type lectin domain. It plays a role in immune system regulation of animals and expressed on B lineage cells, NK cells, monocytes, dendritic cells, and mast cells as a homodimer. Also, this protein associates with CD79A in the B cell antigen receptor (BCR) complex following antigen stimulation and dampens BCR signaling through interactions with the phosphatase SHP1. It binding to Semaphorin 4D induces cytokine production by monocytes and dendritic cells, inhibits SCF R/ckit induced mast cell proliferation and activation, and inhibits the cytolytic activity of NK cells. Moreover, BCR signaling enhances phosphorylation of CD72 and its recruitment of SHP-1. Recombinant protein corresponding to aa117-359 from human CD72 fused to hIgG-His-Tag, at C-terminal, expressed in E. coli.. Molecular Weight: ~55.3kD (485aa) Amino Acid Sequence: ADPRYLQVSQ QLQQTNRVLE VTNSSLRQQL RLKITQLGQS AEDLQGSRRE LAQSQEALQV EQRAHQAAEG QLQACQADRQ KTKETLQSEE QQRRALEQKL SNMENRLKPF FTCGSADTCC PSGWIMHQKS CFYISLTSKN WQESQKQCET LSSKLATFSE IYPQSHSYYF LNSLLPNGGS GNSYWTGLSS NKDWKLTDDT QRTRTYAQSS KCNKVHKTWS WWTLESESCR SSLPYICEMT AFRFPDLEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGKH HHHHH Applications: Suitable for use in SDS-PAGE. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 55.3
• NCBI: 001773
• UniProt: P21854
• Reinheit: 90% (SDS-PAGE) Endotoxin: 1EU/ug (LAL).
• Formulierung: Supplied as a liquid in 50mM Tris-HCl, pH 6.8, 2mM DTT, 0.2M sodium chloride, 50% glycerol.