Beta toxins bind at site-4 of sodium channels and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Has a selective effect toward Nav1.7/SCN9A which plays a role in pain mechanisms, and especially in the development of inflammatory pain. Shows no lethality toward mice. Source: Recombinant protein corresponding to Centruroides elegans Beta-toxin CeII8, fused to His-Tag at N-terminal, expressed in Baculovirus. Amino Acid Sequence: KKDGYPVNME ECRYNCWKNA YCDKLCKEKK GQSGYCYGWN LSCWCIGLPD NTNTKMNPFC QTAD Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.
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