Hemagglutinin, Recombinant, Influenza A Virus, aa16-339, His-SUMO-Tag

Produktübersicht

• Artikelname: Hemagglutinin, Recombinant, Influenza A Virus, aa16-339, His-SUMO-Tag
• Artikelnummer: USB-584808
• Hersteller Artikelnummer: 584808
• Alternativnummer: USB-584808-20,USB-584808-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Source: Recombinant protein corresponding to aa16-339 from Hemagglutinin Influenza A virus, fused to 6X His-SUMO-Tag, at N-terminal, expressed in E.coli. Molecular Weight: ~52.2kD Amino Acid Sequence: DQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCRLSGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIVEKENPANGLCYPGNFNDYEELKHLLTRVTHFEKIKILPRDQWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLVIWGIHHPNDDTEQRTLYQNVGTYVSVGTSTLNKRSIPEIATRPKVNGQGGRMEFSWTLLETWDVINFESTGNLIAPEYGFKISKRGSSGIMKTEKTLENCETKCQTPLGAINTTLPFHNIHPLTIGECPKYVKSDRLVLATGLRNVPQIES Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 52.2
• UniProt: Q67282
• Reinheit: 90% (SDS-PAGE)
• Formulierung: Supplied as a lyophilized powder from 20mM Tris-HCl, 0.5M sodium chloride, pH 8.0, 6% trehalose. Reconstitute with sterile ddH2O to a concentration of 0.1-1mg/ml.