Plays a role in regulating cardiac sodium current, decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current, cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. Recombinant protein corresponding to aa1-351 from Glycerol-3-phosphate dehydrogenase 1-like protein, fused to GST-Tag at N-terminal, expressed in E.coli. Molecular Weight: ~65.4kD Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized CCL5 at 2ug/ml can bind human GPD1L, the EC50 of human GPD1L protein is 47.34-66.33ug/ml. Amino Acid Sequence: MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
