Teriflunomide (Leflunomide EP Impurity B) is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzymes teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a.. Synonyms: N-(4-Trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide, 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-beuteamide, LEF-M, Teriflunomide, Leflunomide EP Impurity B, Aubagio, A1726, (2Z)-2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide, Femorix, HMR 1726, SU 20 CAS No: 163451-81-8 Molecular Formula: C12H9F3N2O2 Molecular Weight: 270.21 Appearance: White solid Purity: 95% Melting Point: 222-232C Solubility: DMSO (Slightly), Methanol (Sparingly) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
270.21
Reinheit:
95%
Formulierung:
White solid
CAS Nummer:
[163451-81-8]
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