| Suitable for use in nucleic acid inhibition. Actinomycin D inhibits the proliferation of cells in a cell-cycle nonspecific way by forming a stable complex with DNA (via deoxyguanosine residues), thus inhibiting DNA-primed RNA synthesis. It is used in cell culture as a selection agent. Antibiotic. Antitumor compound. Cytotoxic. Apoptosis inducer. RNA synthesis inhibitor. DNA intercalating agent. Mcl-1 expression inhibitor. p53 pathway activator. Source: Streptomyces sp. Synonyms: Streptomyces antibioticus, 2-Amino-(N,N)-1-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1]-[1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide, Dactinomycin, Actinomycin IV, Actinomycin C1, Actactinomycin A IV, Actinomycin 7, Dilactone Actinomycindioic D Acid, Lyovac Cosmegen, Cosmogen, Meractinomycin CAS No: 50-76-0 Molecular Formula: C62H86N12O16 Molecular Weight: 1255.43 Appearance: Orange to bright red crystaline powder Purity: 98% Solublility (DMSO, 50mg/ml): Clear orange solution Specific Rotation: -293~-329 Melting Point: 243~248C (lit) Crystallinity: Conforms Loss on Drying: 5% DNase: None Detected RNase: None Detected Protease: None Detected Endotoxin: 0.5EU/mg Total Impurities (HPLC): 2% Storage and Stability: May be stored at 4C. Stable for 12 months after receipt. |
