Human alpha 1 Antitrypsin or Human A1-antitrypsin (A1AT), also known as serum trypsin inhibitor, protects tissue from enzymes from inflammatory cells, especially elastase and is present in human blood. Disorders of the enzyme include human alpha-1 antitrypsin deficiency, a hereditary disorder in which lack of Human alpha-1 Antitrypsin AAT (A1AT) leads to uninhibited tissue breakdown during inflammation. Studies indicate that this causes pulmonary emphysema and leads to liver cirrhosis in severe cases. Human alpha-1 antitrypsin protects the lungs from the harmful effects of human neutrophil elastase. Source: Alpha-1 Antitrypsin from human plasma Molecular Weight: ~54kD Extinction Coefficient: As Reported Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
54
Reinheit:
95% (SDS-PAGE)
Formulierung:
Supplied as a lyophilized powder from a sodium phosphate buffer. Reconstitute with sterile ddH2O.
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