Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway. Sequence (linear): H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH Synonyms: H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH, DRVYIHPF CAS No: 5649-07-0 Molecular Formula: C49H69N13O12 Molecular Weight: 1032.18 Appearance: White to off-white lyophilized powder Purity: 95% (HPLC) MS: Conforms to reference Solubility: Water: 10mg/ml (9.56mM) DMSO: 10mg/ml (9.56mM, ultrasonic and warming and heat to 60C) Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
1032.18
Reinheit:
95% (HPLC)
Formulierung:
White to off-white lyophilized powder
CAS Nummer:
[5649-07-0]
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