a1-Antitrypsin, Recombinant, Human, aa25-418 (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI, SERP1NA1, SerpinA1)

Produktübersicht

• Artikelname: a1-Antitrypsin, Recombinant, Human, aa25-418 (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI, SERP1NA1, SerpinA1)
• Artikelnummer: USB-A2298-27Q
• Hersteller Artikelnummer: A2298-27Q
• Alternativnummer: USB-A2298-27Q-100,USB-A2298-27Q-500
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

Alpha 1 proteinase inhibitor (Antitrypsin) has a characteristic secondary structure of beta sheets and alpha helices. That is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leukocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Also Increase in Antitrypsin occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Antitrypsin is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis. Recombinant protein corresponding to aa25-418 of human a1-Antitrypsin expressed in E. coli. Uniprot/Swiss Accession: P01009 Molecular Weight: ~44.4kD Amino Acid Sequence: MEDPQGDAAQ KTDTSHHDQD HPTFNKITPN LAEFAFSLYR QLAHQSNSTN IFFSPVSIAT AFAMLSLGTK ADTHDEILEG LNFNLTEIPE AQIHEGFQEL LRTLNQPDSQ LQLTTGNGLF LSEGLKLVDK FLEDVKKLYH SEAFTVNFGD TEEAKKQIND YVEKGTQGKI VDLVKELDRD TVFALVNYIF FKGKWERPFE VKDTEEEDFH VDQVTTVKVP MMKRLGMFNI QHCKKLSSWV LLMKYLGNAT AIFFLPDEGK LQHLENELTH DIITKFLENE DRRSASLHLP KLSITGTYDL KSVLGQLGIT KVFSNGADLS GVTEEAPLKL SKAVHKAVLT IDEKGTEAAG AMFLEAIPMS IPPEVKFNKP FVFLMIDQNT KSPLFMGKVV NPTQK Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 44.4
• NCBI: 000286
• UniProt: P01009
• Reinheit: 90% by SDS PAGE.
• Formulierung: Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 1mM DTT, 2mM EDTA, 10% glycerol.