Betamustine acts as an alkylating agent causing intra-strand and inter-strand cross-links between DNA bases. After intravenous infusion it is extensively metabolised in the liver by cytochrome p450. >95% of the drug is bound to protein - primarily albumin. Only free bendamustine is active. Elimination is biphasic with a half-life of 6-10 minutes and a terminal half-life of approximately 30 minutes. It is eliminated primarily by the renal route. Solubility: Methanol, Hot Water Melting Point: 150-152C Method for Determining Identity: Proton NMR Spectroscopic and Mass Spectrometric Analysis TLC Conditions: SiO2, Dichloromethane: methanol: Acetic Acid, 7ml: 3ml: 10 drops, Visualized with UV and AMCS, Single spot, Rf=0.35 Choride Content: 7.93% Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Toxicity and Hazards: Due to the potential danger associated with the use of some of United States Biological biochemicals, all products should be handled by qualified personnel only, trained in laboratory procedures, and familiar with potential hazards. Information is not available on the possible hazards of many experimental compounds. The absence of a warning must not be interpreted as indication of safety. The ultimate responsibility for the proper handling of any and all chemicals lies with the user.
Molekulargewicht:
399.75
Reinheit:
~90%
Formulierung:
Supplied as an off-white solid
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
