4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8), CAS [[327036-89-5]]

Produktübersicht

• Artikelname: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8), CAS [[327036-89-5]]
• Artikelnummer: USB-B1078-01E
• Hersteller Artikelnummer: B1078-01E
• Alternativnummer: USB-B1078-01E-10
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). Melting Point: As Reported Solubility: As Reported Method for Determining Identity: Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: As Reported Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Store under inert atmosphere in amber vial. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Produkteigenschaften

• Reinheit: ~90%
• CAS Nummer: [327036-89-5]