Bone Morphogenetic protein 7b, Human, Control Peptide (BMP7)

Produktübersicht

• Artikelname: Bone Morphogenetic protein 7b, Human, Control Peptide (BMP7)
• Artikelnummer: USB-B2553-32C
• Hersteller Artikelnummer: B2553-32C
• Alternativnummer: USB-B2553-32C-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: ELISA

Produktbeschreibung

Control Peptide for (affinity purified) and (antiserum). 21aa peptide from Human BMP7, Mid-region. Bone Morphogenetic Proteins belong to the TGF-beta superfamily, whose members are widely represented throughout the animal kingdom. The BMPs are important regulators of key events in the processes of bone formation during embryogenesis, postnatal growth, remodeling and regeneration of the skeleton. The BMPs function by binding to a receptor complex that is found on all normal cells and is composed of type I and II receptors. The primary unit of bone formation is osteoblast, the bone-forming cell. These osteoblast cells respond to physical loading by transducing signals that alter gene expression patterns, and Cbfa (core binding factor), the osteoblast specific transcription factor plays an important role in osteoblast differentiation and function. Localization studies in both human and mouse tissues have demonstrated high levels of mRNA expression and protein synthesis for various BMPs in kidney, heart, lung, small intestine, limb bud and teeth. Several BMPs have been implicated in early skeletal development, including BMP-2, -4, -5, -7, -14 (CDMP-1/GDF-5), other members, such as BMP-3, -6, -7 and -13 (CDMP-2/GDF-6) may be involved in later stages of skeletal formation. BMP7 or OP1, a 431-amino acid polypeptide that includes a secretory signal sequence, (Chr 20), is expressed in kidney, bladder and brain. Induces cartilage and bone formation may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. It plays a role in calcium regulation and bone homeostasis. Storage and Stability: May be stored at 4C for short-term only. For long-term storage, store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: Purified
• Formulierung: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.