L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer's disease, and the secondary effects of diabetes. Synonyms: ß-Ala-His-OH, N-(beta-Alanyl)-L-histidine, NSC 524045, Sevitin, beta-Alanyl-L-histidine, beta-Alanylhistidine, Carnosine, 2: PN: WO2009033754 PAGE: 98 Claimed Protein, Dragosine, Ignotin, Ignotine, Karnozin, beta-Alanyl-L-histidine CAS No: 305-84-0 Molecular Formula: C9H14N4O3 Molecular Weight: 226.23 Appearance: White to off-white lyophilized powder Purity: 98% (HPLC) Optical Rotation [alpha]20: +21 2 Melting Point: 250-265C (lit) Storage and Stability: Lyophilized powder may be stored at 4C for short-term only. Stable for 12 months at -20C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
226.24
Reinheit:
98% (HPLC)
Formulierung:
White to off-white lyophilized powder
CAS Nummer:
[305-84-0]
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