CD51 (Integrin alphaV, Vitronectin alpha Subunit Receptor, VNR), IgG1, Clone: [AV1], Mouse, Monoclonal
Artikelnummer:
USB-C2405-15A
- Bilder (0)
| Artikelname: | CD51 (Integrin alphaV, Vitronectin alpha Subunit Receptor, VNR), IgG1, Clone: [AV1], Mouse, Monoclonal |
| Artikelnummer: | USB-C2405-15A |
| Hersteller Artikelnummer: | C2405-15A |
| Alternativnummer: | USB-C2405-15A-500 |
| Hersteller: | US Biological |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, WB |
| Immunogen: | Human integrin alphaVbeta3 heterodimer isolated from placenta |
| ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Applications: Suitable for use in Western Blot, Flow Cytometry and Function-blocking of integrin alphaV-mediated adhesion to ECM proteins. Other applications not tested. Recommended Dilutions: Western Blot: under non-reducing conditions recognizes a band at ~165kD corresponding to integrin alphaV. Does not recognize the reduced protein. Flow Cytometry: 1:5-1:50 Function Blocking: 1:5-1:20, in HEPES buffer pH 7.4 containing 1mM Mn++ and 1mM Mg++ Optimal dilution determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
Produktgarantie und fachkundiger Support
