CD54 (ICAM-1, Intercellular Adhesion Molecule1, Human Rhinovirus Receptor, BB2, Major group rhinovirus receptor, P3.58), IgG1, Clone: [HM.2], Mouse, Monoclonal

Produktübersicht

• Artikelname: CD54 (ICAM-1, Intercellular Adhesion Molecule1, Human Rhinovirus Receptor, BB2, Major group rhinovirus receptor, P3.58), IgG1, Clone: [HM.2], Mouse, Monoclonal
• Artikelnummer: USB-C2409-10R
• Hersteller Artikelnummer: C2409-10R
• Alternativnummer: USB-C2409-10R-100
• Hersteller: US Biological
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: ELISA, IHC, IP
• Immunogen: Human CD54.

Produktbeschreibung

The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is an essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leukocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes. Applications: Suitable for use in staining of in vitro cultured cells, Immunohistochemistry (frozen and paraffin), ELISA, and Immunoprecipitation. Other applications not tested. Recommended Dilution: Immunohistochemistry: 1:50 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [HM.2]
• Isotyp: IgG1
• Reinheit: Purified by Protein G affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.