LAIR1 (Leukocyte-associated Immunoglobulin-like Receptor 1, LAIR-1, hLAIR1, CD305), Goat
Artikelnummer:
USB-C2549-32C
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| Artikelname: | LAIR1 (Leukocyte-associated Immunoglobulin-like Receptor 1, LAIR-1, hLAIR1, CD305), Goat |
| Artikelnummer: | USB-C2549-32C |
| Hersteller Artikelnummer: | C2549-32C |
| Alternativnummer: | USB-C2549-32C-100 |
| Hersteller: | US Biological |
| Wirt: | Goat |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC, WB |
| Immunogen: | Synthetic peptide corresponding to C-NDTEDVSQASPSE, from the internal region of human LAIR1. |
| Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. Applications: Suitable for use in Peptide ELISA, Immunohistochemistry and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Western Blot: 1-3ug/ml, observed in human lymph node lysates on ~28kD bands Immunohistochemistry (paraffin): 3.75ug/ml. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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