| Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective non-steroidal anti-inflammatory drugs (NSAIDs). Synonyms: Celecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide CAS Number: 169590-42-5 Molecular Formula: C17H14F3N3O2S Molecular Weight: 381.37 Appearance: White solid Purity: 99% Melting Point: 157-159C Solubility: DMSO, Dichloromethane, Ether, Ethyl Acetate, Methanol. Soluble in DMSO at 200mg/ml, soluble in ethanol at 100mg/ml, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-50uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Store at -20C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Pfizer Compound |
