Cerebellin Precursor, CT, Control Peptide (Cbln1, Precerebellin)
Artikelnummer:
USB-C2790-52A
Hersteller Artikelnummer:
C2790-52A
Alternativnummer:
USB-C2790-52A-50
Hersteller:
US Biological
Kategorie:
Molekularbiologie
Applikation:
WB
Synthetic peptide 16aa near the carboxy- terminus human precerebellin (Genbank accession No. P23435). Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q (1). Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka- dependent signaling pathway (2), and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (3). The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus (4). Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin posseses functions other than those already stated (5). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 2-4ug/ml, Blocks the antibody (Cat. C2790-52) activity completely by incubating the peptide with equal volume of antibody for 30 min at 37C. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20C. Aliquots are stable for 6 months after receipt at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
