CHOP (C/EBP-homologous Protein, C/EBP-homologous Protein 10, CHOP10, CHOP-10 CEBPZ, DNA Damage-inducible Transcript 3 Protein, DDIT3, DDIT-3, Growth Arrest and DNA Damage-inducible Protein GADD153, MGC4154), Clone: [11C1019D46F1],
CHOP (C/EBP-homologous Protein, C/EBP-homologous Protein 10, CHOP10, CHOP-10 CEBPZ, DNA Damage-inducible Transcript 3 Protein, DDIT3, DDIT-3, Growth Arrest and DNA Damage-inducible Protein GADD153, MGC4154), Clone: [11C1019D46F1],
CHOP (C/EBP-homologous Protein, C/EBP-homologous Protein 10, CHOP10, CHOP-10 CEBPZ, DNA Damage-inducible Transcript 3 Protein, DDIT3, DDIT-3, Growth Arrest and DNA Damage-inducible Protein GADD153, MGC4154), Clone: [11C1019D46F1],
Artikelnummer:
USB-C5064-05B
Hersteller Artikelnummer:
C5064-05B
Alternativnummer:
USB-C5064-05B-100
Hersteller:
US Biological
Wirt:
Rabbit
Kategorie:
Antikörper
Applikation:
IP, WB
Immunogen:
Synthetic peptide corresponding to residues surrounding Leu159 of human CHOP. Species Sequence Homology: human and rat
CHOP was identified as a C/EBP-homologous protein that inhibits C/EBP and LAP in a dominantnegative manner. CHOP expression is induced by certain cellular stresses including starvation and the induced CHOP suppresses cell cycle progression from G1 to S phase. Later it was shown that, during ER stress, the level of CHOP expression is elevated and CHOP functions to mediate programmed cell death. Studies also found that CHOP mediates the activation of GADD34 and Ero1-La expression during ER stress. GADD34 in turn dephosphorylates phospho-Ser51 of eIF2a thereby stimulating protein synthesis. Ero1-La promotes oxidative stress inside the endoplasmic reticulum (ER). The role of CHOP in the programmed cell death of ER-stressed cells is correlated with its role promoting protein synthesis and oxidative stress inside the ER. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
