| Clavulanic acid is a beta-lactam antibiotic produced by several species of the genus Streptomyces. The free acid degrades and is isolated and maintained as either the sodium or potassium salt. Clavulanate is a weak antibiotic but is a potent inhibitor of beta- lactamases. In combination with penicillin and cephalosporins it shows potent synergistic activity. Clavulanic acid is a suicide inhibitor, covalently binding to a serine residue in the active site of the beta-lactamase. Synonyms: Timentin, Ticarcillin, MM 14151, [2R-(2alpha,3Z,5alpha)]-3-(2-hydroxyethylidene)-7-oxo-4-oxa- 1-azabicyclo[3.2.0]heptane-2-carboxylate potassium salt CAS No: 61177-45-5 Molecular Formula: C8H8KNO5 Molecular Weight: 237.25 Appearance: Brownish orange solid Purity: 95% Melting Point: >170.5C (dec) Solubility: Water (Hot, Sparingly) Atmosphere: Inert Gas Method for Determining Identity: Proton NMR (D2O) Spectroscopic and Mass Spectrometric Analysis TLC Conditions: C18, Acetonitrile: Water= 9:5, Visualized with UV and Ninhydrin, single spot, Rf= 0.55 Potassium: ~16% by Ion chromatography Elemental Analysis: Calculated: %C: 40.50, %H: 3.40, %N: 5.90 Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under Inert atmosphere. |
