CLC6, Rat (Clcn6, Chloride Channel) Control Peptide

Produktübersicht

• Artikelname: CLC6, Rat (Clcn6, Chloride Channel) Control Peptide
• Artikelnummer: USB-C5837-45
• Hersteller Artikelnummer: C5837-45
• Alternativnummer: USB-C5837-45-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: ELISA, WB

Produktbeschreibung

A 19aa Peptide sequence near the C-terminus of rat CLC-6. Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential stabilization, signal transduction, and transepithelial transport. Mutations in CIC genes have been linked with several human diseases including myotonias (Thomsens disease), cystic fibrosis, Bartters syndrome type III, Dents disease, and X-linked recessive nephrolithiasis. In mammals, CLC proteins form a superfamily of at least 9 different genes (CLC1-7 also known as CLCN1-7 and CLK1-2 or CLCKa and CLCKb). Additional forms of these proteins are obtained by alternative splicing. All CLC proteins (~700-1000 aa) are predicted to contain 10 (possibly 12) transmembrane domains.Except CLC-1 and CLC-K1/K2 that are specific for kidney, most other CLC are widely distributed in various tissues. Rat CLC-6 is 803 aa membrane protein (human CLC-6 869 aa, mouse 870 aa) (1). Alternative splicing of CLC-6 generates 4 isoforms, CLC-6a-6d (2). CLC-6a is the full length form, while forms 6b-6d are truncated at their C-terminus and they contain 4 TM (CLC-6b and CLC-6d) or 7 TM (form CLC-6c). CLC-6a and CLC-6c are the most abundant isoforms with CIC-6a being the most abundant isoform with CLC-6a being ubiquitously expressed and CLC-6c being limited to kidney (1, 2). CLC-6 also is expressed in testis, ovary, small intestine, brain, and skeletal muscle.

Produkteigenschaften

• Reinheit: Highly purified
• Formulierung: Supplied as a liquid in PBS, pH 7.2.