Isolated from Streptomyces conglobatus, conglobatin has a unusual dimeric macrolide dilactone structure with pendant oxazole groups. It exhibited an IC50 of 0.63ug/ml in a NFAT-dependent transcription assay. No toxicity was observed at doses up to 1000mg/kg when administered to mice either orally or interperitoneally. Hsp90 inhibitor. Source: Streptomyces conglobatus MST-AS5530 Synonyms: (3Z,5R,7S,8S,11Z,13R,15S,16S)-3,5,7,11,13,15-hexamethyl-8,16-bis(1, 3-oxazol-5-ylmethyl)-1,9-dioxacyclohexadeca-3,11-diene-2,10-dione CAS No: 72263-05-9 Molecular Formula: C28H38N2O6 Molecular Weight: 498.62 Purity: 95% (HPLC) Appearance: White lyophilized powder Solubility: Ethanol, Methanol, DMF or DMSO. Poor water solubility Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with ethanol, methanol, DMF or DMSO.. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molekulargewicht:
498.62
CAS Nummer:
[72263-05-9]
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