Synthetic peptide corresponding to C-RRDSSWSETSEA, from CXCR3, at C-terminal (NP_001495.1).
CXCR3 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10, Mig and I-TAC. The protein is mainly expressed on activated Th1 cells, B cells and natural killer cells. It is activated by the interferon-gamma-inducible chemokines CXCL9, CXCL10 and CXCL11, with CXCL11 having the highest affinity. Upon activation, CXCR3 activates pertussis toxin-sensitive G proteins of the Galphai class and mediates, among others, chemotaxis, calcium flux and activation of kinases such as p44/p42 MAPK and Akt. The protein and its ligands are upregulated in a wide variety of inflammatory diseases, implying a role for CXCR3 in serious disorders (e.g. rheumatoid arthritis, multiple sclerosis, transplant rejection, atherosclerosis and inflammatory skin diseases) and thus has attracted considerable attention as a drug target. The gene encoding for human CXCR3 is localized in the chromosomal region Xq13. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:64,000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
