| A formyl peptide receptor antagonist immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin H is a natural cyclic undecapeptide that selectively antagonizes the formyl peptide receptor at concentrations ranging from 0.1 to 10uM. Unlike cyclosporin A, Cyclosporin H does not bind cyclophilin to evoke an immunosuppressant response. Cyclosporin H has been reported to inhibit phorbol ester-mediated effects in mouse skin and block calcium/calmodulin-dependent EF-2 phosphorylation in vitro. Synonyms: 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv., 5-(N-Methyl-D-valine)-Cyclosporin A, Sandoz 37-839, FPR-1 (formyl peptide receptor 1) Inhibitor, D-MeVal11-Cyclosporine, CsH CAS No: 83602-39-5 Molecular Formula: C62H111N11O12 Molecular Weight: 1202.63 Appearance: White to off-white powder Purity: 95% Method for Determining Identity: Proton NMR (CDCl3) Spectroscopic and Mass Spectrometric Analysis. TLC Conditions: SiO2, Dichloromethane: Methanol: 9:1, Visualized with UV and AMCS, Single spot, Rf=0.6 Melting Point: 143-150C Solubility: Chloroform, Methanol, Dichloromethane: Slightly Soluble, Soluble in Ethanol: 20mg/ml, DMSO: 40mg/ml, DMF, Acetone, Ethyl acetate, Water: Insoluble Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
