| An antitumor agent. A topoisomerase II inhibitor. A derivative of podophyllotoxin that has major activity against a number of tumors, including germ cell neoplasms, small cell lung cancer, and malignant lymphoma. Induces apoptosis in human T cells, mouse thymocytes, and HL-60 human leukemia cells. Synonyms: 4'-Demethylepipodophyllotoxin, 9-(4,6-O-ethylidene-beta-D-glucopyranoside), (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-beta-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3,4:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, EPEG, VP 16-213, VePesid, Vepesid J, Zuyeyidal, trans-Etoposide CAS No: 33419-42-0 Molecular Formula: C29H32O13 Molecular Weight: 588.56 Appearance: White solid Purity: 98% Melting Point: 253-255C Method for Determining Identity: Proton H NMR (CD3OD) Mass Spectroscopic analysis TLC Conditions: SiO2, Dichloromethane, Methanol, 9:1, Visualized with UV and AMCS, Single spot, Rf=0.5. Solubility: Chloroform (Slightly), Methanol (Slightly) Specific Rotation: -104.3 (c-0.6, Chloroform) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
