Everolimus is an immunosuppressant analog of rapamycin (sirolimus) and inhibits growth factor-mediated proliferation of hematopoietic and nonhematopoietic cells. Everolimus shows a potent inhibitory effect on posttransplant lymphoproliferative disorder (PTLD)-derived cells in vitro and in vivo, in a dose range that can prevent allograft rejection, and may demonstrate activity in both the prevention and treatment of PTLDs in transplant patients. Synonyms: Afinitor, Certican, RAD-001, Zortress, 40-O-(2-Hydroxyethyl)rapamycin, 42-O-(2-Hydroxy)ethyl Rapamycin, RAD, RAD 001, SDZ-RAD, XIENCE V CAS No: 159351-69-6 Molecular Formula: C53H83NO14xH2O Molecular Weight: 958.22 Purity: 98% (HPLC, TLC) Appearance: White to off-white powder Elemental Analysis: Calculated: C 65.51%, H 8.78%, N 1.43% Melting Point: 90-115C Cis-Isomer (HPLC): 15% Solubility: Soluble in DMSO at 100mg/ml, soluble in ethanol at 100mg/ml, very poorly soluble in water, maximum solubility in plain water is estimated to be about 1-10uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molekulargewicht:
958.22
Reinheit:
98% (HPLC, TLC)
Formulierung:
White to off-white powder
CAS Nummer:
[159351-69-6]
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