Flt4, Mouse, Control Peptide (Fms-like Tyrosine Kinase 4)

Produktübersicht

• Artikelname: Flt4, Mouse, Control Peptide (Fms-like Tyrosine Kinase 4)
• Artikelnummer: USB-F4601-03
• Hersteller Artikelnummer: F4601-03
• Alternativnummer: USB-F4601-03-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: ELISA

Produktbeschreibung

Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. This process is known as angiogenesis (sprouting of new capillary vessels from pre-existing vasculature). Study of tumor angiogenesis has led to the identification of several proteins including basic fibroblast growth factor (bFGF) and vascular endothelial growth factor. VEGF acts by interacting with a family of largely endothelial-specific receptor tyrosine kinases that includes VEGFR-1 (flt-1/flk-2), VEGFR-2 (flk-1/KDR), and VEGFR-3/Flt-4. Disruption of VEGFRs interferes with differentiation of endothelial cells and it is lethal for the embryo. FLT-4 (mouse/rat 1363aa, human 1298aa, ), a receptor protein tyrosine kinase, is a receptor for VEGF-C. It is type 1 membrane protein. It is expressed in adult lung, and liver, and in fetal liver, brain, intestine, and placenta. Source: 20aa peptide of mouse FLT4 Location: ~C-terminal, Cytoplasmic Species Sequence Homology: Rat-85%, Human-73%. No significant sequence homology is seen with VEGFR1 or VEGFR2 or other tyrosine kinases. Applications: ELISA: Use 50-100ng of control peptide/well. Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: Purified
• Formulierung: Supplied as a lyophilized powder from PBS, 0.05% sodium azide.