A 20 aa peptide sequence within the cytoplasmic, C-terminus of mouse GLAR3 (1) was coupled to KLH. Galanin is a 29 aa C-terminally amidated (30 aa, non-amidated in humans), highly conserved but unique neuroendocrine peptide originally isolated from intestine. The first 14 aa are fully conserved in almost all species. Galanin is found in the brain and the gut. It modulates a variety of physiological processed including cognition/memory, sensory/pain processing, neurotransmitter/hormone secretion, and feeding behavior. Several N-terminally elongated (-7-29 and -9-29) or truncated biologically active forms of galanin have also been isolated. Galanin antagonists are chimeric peptides generated by linking the amino terminal portion of galanin to substance P (galantide, M15), bradykinin (M35), the neurokinin antagonist spantide (C7) or an idealized alpha helical region (M40) (see review in refs 2 by Kask et al 1995). Galanin mediated its biological effects by interacting with high affinity cell surface G-protein coupled receptors (GALR1-3). Rat GALR3 (human 368 aa) encodes a protein of 370 aa with 35% and 52% identity with GALR1 and GALR2. The rat and human GALR3 are ~90% conserved. Rat GALR3 is expressed in heart, spleen, and testes. Galanin binding to GALR3 can be displaced by galanin and galanin analogues. However, human galanin, galanin (1-16), and M40 show lower affinity to GALR3.
Reinheit:
Highly purified
Formulierung:
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide
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