Gefitinib, Free Base (Iressa), CAS [[184475-35-2]]

Produktübersicht

• Artikelname: Gefitinib, Free Base (Iressa), CAS [[184475-35-2]]
• Artikelnummer: USB-G2023-95A
• Hersteller Artikelnummer: G2023-95A
• Alternativnummer: USB-G2023-95A-1
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

EGFR tyrosine kinase inhibitor that binds to the ATP-binding site of the enzyme. The functions of the EGFR tyrosine kinase in activating the Ras signal transduction cascade and malignant cell growth are thus inhibited. It has been shown that a mutation in the EGFR tyrosine kinase domain is responsible for activating anti-apoptotic pathways in gefitinib-sensitive non-small cell lung cancers. These mutations tend to increase sensitivity to tyrosine kinase inhibitors including gefitinib and erlotinib. The adenocarcinoma subset of non-small cell lung cancer histologies often have these mutations, which are commonly found in Asians, women, and non-smokers. Purity: 99% (HPLC, TLC) Appearance: White to off-white powder Melting Point: 188-193C (lit) Solubility: Soluble in DMSO at ~100mg/ml, poorly soluble in ethanol, very poorly soluble in water. Maximum solubility in plain water is ~5-20uM. Elemental Analysis: Calculated: C - 59.13% H - 5.41% Cl - 7.93% F - 4.25% N - 12.54% Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 6 months after receipt at -20C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Molekulargewicht: 446.9
• CAS Nummer: [184475-35-2]