GITR (TNFRSF18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNFR family receptor, CD_antigen: CD357, AITR, UNQ319/PRO364) (APC), Clone: [11E203 DTA-1], Rat, Monoclonal
Artikelnummer:
USB-G2035-09N1
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| Artikelname: | GITR (TNFRSF18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNFR family receptor, CD_antigen: CD357, AITR, UNQ319/PRO364) (APC), Clone: [11E203 DTA-1], Rat, Monoclonal |
| Artikelnummer: | USB-G2035-09N1 |
| Hersteller Artikelnummer: | G2035-09N1 |
| Alternativnummer: | USB-G2035-09N1-100 |
| Hersteller: | US Biological |
| Wirt: | Rat |
| Kategorie: | Antikörper |
| Applikation: | FC |
| Immunogen: | Mouse CD25+ CD4+ T cells |
| GITR or TNFRSF18 is a 241aa novel member of the tumor necrosis factor receptor superfamily and a receptor for TNFSF18. It has three extracytoplasmic cysteine-rich pseudorepeats, a small cytoplasmic tail and a DEATH domain. It is an essential regulator of immune responses to self tissues and pathogens and plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. It is known to be involved in regulation of CD3-driven T-cell activation and programmed cell death and also in interactions between activated T-lymphocytes and endothelial cells. In mammalian cells it mediates NF-kappa-B activation via TRAF2 and modulates T lymphocyte survival in peripheral tissues. It is mostly expressed in lymph node, peripheral blood leukocytes and weakly expressed in spleen. GITR and its ligand are also known to be involved in atopic dermatitis. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.25ug/10e6 cells in 100ul Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
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