Glucagon-like Peptide 2 Receptor, Human, Control Peptide (GLP2R)

Produktübersicht

• Artikelname: Glucagon-like Peptide 2 Receptor, Human, Control Peptide (GLP2R)
• Artikelnummer: USB-G2040-39F
• Hersteller Artikelnummer: G2040-39F
• Alternativnummer: USB-G2040-39F-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: ELISA

Produktbeschreibung

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide. The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and up regulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLPs are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration. GLP1 Receptor, a 489aa peptide in mouse, 463aa in rat and human (chr 6p21), serves as receptor for GLP1. The activity of this receptor is mediated by G protein which activate adenylyl cyclase. GLP1 Receptor is mainly expressed in pancreatic islets, stomach, and lung. Source: 18aa peptide of human GLP2R Location: ~N terminus, Extracellular Species Sequence Homology: Mouse-77%, Rat-72%. Applications: ELISA: Control peptide can be used to coat ELISA plates at 1ug/ml and detected with antibodies (See G2040-39E). Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Produkteigenschaften

• Reinheit: Purified
• Formulierung: Supplied as a lyophilized powder from PBS, 0.05% sodium azide.