Glutamate Transporter EAAT4, Rat (Excitatory Amino Acid Transporter 4) Control Peptide

Produktübersicht

• Artikelname: Glutamate Transporter EAAT4, Rat (Excitatory Amino Acid Transporter 4) Control Peptide
• Artikelnummer: USB-G4003-93A
• Hersteller Artikelnummer: G4003-93A
• Alternativnummer: USB-G4003-93A-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie

Produktbeschreibung

A 21AA synthetic peptide near the cytoplasmic, carboxy terminus of rat EAAT4 (1). Peptide was found unique to EAAT4 without significant homology to other glutamate transporters. It is 100% homologous in mouse and 90% in human EAAT4. Glutamate is the main excitatory neurotransmitter in the brain. To date five glutamate Transporters have been cloned: GLAST (EAAT1), GLT1 (EAAT2), EAAC1 (EAAT3), EAAT4, and EAAT5. These transporters are believed to be critical in reducing potentially toxic extracellular concentration of glutamate by rapid uptake into nerve terminals and glial cells. Glutamate transporters (525-573aa) display about 55% homology and are predicted to contain up to 6-10 transmembrane domains. Immunolocalization studies indicate that GLT1 is localized in astroglial cells throughout the brain and spinal cord. EAAC1 is specific for certain neurons and purkinje cells, and specifically enriched in cortex, hippocampus, and caudate-putamen and confined to presynaptic and postsynaptic elements. GLAST has been observed in both neuron and astroglia. It is most abundant in Bergmann glia, cortex, hippocampus and cerebellum. EAAT4 has properties of ligand gated Cl-channel. It is localized mainly in cerebellar Purkinje cells in rat and human CNS. EAAT5 has only been cloned from human. It is primarily expressed in retina.

Produkteigenschaften

• Reinheit: Highly purified
• Formulierung: Supplied as a liquid in PBS, pH 7.2