Integrin alpha5, beta1 (VLA5, Fibronectin Receptor, Very Late Antigen, CD49)

Produktübersicht

• Artikelname: Integrin alpha5, beta1 (VLA5, Fibronectin Receptor, Very Late Antigen, CD49)
• Artikelnummer: USB-I7661-35L
• Hersteller Artikelnummer: I7661-35L
• Alternativnummer: USB-I7661-35L-25
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: WB

Produktbeschreibung

The alpha5 beta1 integrin mediates cell adhesion and migration on fibronectin, a glycoprotein critical for normal vertebrate embryonic development. Indirect evidence reported to date suggests that this receptor also functions in the deposition of fibronectin matrices. Integrin alpha5/beta1 purified from smooth muscle under nondenaturing conditions by affinity chromatography on fibronectin-sepharose. Applications: Suitable for use in Western Blot, Electrophoresis and Functional Studies. In Functional Studies, liposomes containing Integrin alpha5/beta1 adhere to surfaces coated with fibronectin in an RGD-dependent fashion. Other applications have not been tested. Storage and Stability: Aliquot to avoid repeated freezing and thawing and store at -70C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• NCBI: 002205
• UniProt: P08648
• Reinheit: 95%. Non-reduced SDS-PAGE of 15ug on 5-15% polyacrylamide slab gel and staining with Coomassie blue shows only two main bands at 120kD (beta1 subunit) and 145kD (alpha5 subunit). A weak band at 205kD is due to dimerization of the beta 1 subunit.
• Formulierung: Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 150mM sodium chloride, 2mM MgCl2, containing 0.2% Triton X-100. No preservatives.