Interleukin 1 Receptor Type II (IL-1RII), IgG2a, Clone: [6G5], Mouse, Monoclonal

Produktübersicht

• Artikelname: Interleukin 1 Receptor Type II (IL-1RII), IgG2a, Clone: [6G5], Mouse, Monoclonal
• Artikelnummer: USB-I7663-25K1
• Hersteller Artikelnummer: I7663-25K1
• Alternativnummer: USB-I7663-25K1-100
• Hersteller: US Biological
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: ELISA

Produktbeschreibung

The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1 R I and IL-1 R II) and the IL-1 receptor accessory protein. The IL-1 R II is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1 R I. The decoy IL-1 R II can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1 R II exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [6G5]
• Isotyp: IgG2a
• Reinheit: Purified by Protein G affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.