Interleukin 10 Receptor alpha (IL10RA, IL-10RA, IL-10R-A, CDw210a, HIL-10R, IL-10R1, IL10R) (Azide free) (HRP), Rabbit

Produktübersicht

• Artikelname: Interleukin 10 Receptor alpha (IL10RA, IL-10RA, IL-10R-A, CDw210a, HIL-10R, IL-10R1, IL10R) (Azide free) (HRP), Rabbit
• Artikelnummer: USB-I8432-28C-HRP
• Hersteller Artikelnummer: I8432-28C-HRP
• Alternativnummer: USB-I8432-28C-HRP-200
• Hersteller: US Biological
• Wirt: Rabbit
• Kategorie: Antikörper
• Applikation: ELISA, WB
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 147-175 in the central region of human Interleukin 10 Receptor alpha, UniProt Accession Q13651.

Produktbeschreibung

Interleukin-10 (IL-10) is a cytokine whose main biological function is to suppress the immune response by induction of a signal(s) leading to inhibition of synthesis of a number of cytokines and their cellular receptors. Signal transduction is initiated upon formation of a ternary complex of IL-10 with two of its receptor chains, IL-10R1 and IL-10R2, expressed on the cell membrane. The affinity of IL-10R1 toward IL-10 is very high, which allowed determination of the crystal structure of IL-10 complexed with the extracellular/soluble domain of IL-10R1, while the affinity of IL-10R2 toward either IL-10 or IL-10/sIL-10R1 complex is quite low. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20C. Aliquots are stable at -20C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Note: Applications are based on unconjugated antibody.

Produkteigenschaften

• NCBI: 13651
• UniProt: Q13651
• Reinheit: Purified by Protein A and peptide affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).