Interleukin 13 (IL-13) (Azide Free), Clone: [JES10-5A2], Rat, Monoclonal
Artikelnummer:
USB-I8435-05AX
Hersteller Artikelnummer:
I8435-05AX
Alternativnummer:
USB-I8435-05AX-500
Hersteller:
US Biological
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
ELISA
Immunogen:
Recombinant corresponding to human Interleukin 13 expressed in COS cells.
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1b, TNF-a, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: ELISA: Capture Optimal dilutions to be determined by the researcher. Matched Pair (Sandwich): Capture: I8435-05AX Detection: 228224 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
