HIPPI (Intraflagellar Transport Protein 57 Homolog, Dermal Papilla-derived Protein 8, Estrogen-related Receptor beta-like Protein 1, HIP1-interacting Protein, MHS4R2, IFT57, DERP8, ESRRBL1), Goat
Artikelnummer:
USB-I8444-44A
Hersteller Artikelnummer:
I8444-44A
Alternativnummer:
USB-I8444-44A-100
Hersteller:
US Biological
Wirt:
Goat
Kategorie:
Antikörper
Applikation:
ELISA, WB
Immunogen:
Synthetic peptide corresponding to C-EQPQEYDDPNATISN, from HIPPI, at the internal region of the protein (NP_060480.1).
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5-AAAGACATG-3 present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator, however the relevance of such function remains unclear. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 1-3ug/ml, observed in human and mouse brain lysates on ~49kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
