Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Synonyms: [1,4-Bipiperidine]-1-carboxylic Acid (4S)-4,11-Diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3,4:6,7]indolizino[1,2-b]quinolin-9-yl Ester Hydrochloride Trihydrate, Campto, CPT11, Irinotecan hydrochloride trihydrate CAS No: 136572-09-3 Anhydrous: 100286-90-6, Anhydrous Free Base: 97682 Molecular Formula: C33H45ClN4O9 Molecular Weight: 677.18 Appearance: White to off-white solid Purity (HPLC): 99% Purity (TLC): 99% Melting Point: >245C (dec.) Solubility: Methanol (Sparingly), Soluble in DMSO at 100mg/ml, very poorly soluble in ethanol, soluble in water at 25mg/ml, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
677.18
Reinheit:
99% (HPLC/TLC)
Formulierung:
White to off-white solid
CAS Nummer:
[136572-09-3]
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