Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin), CAS [[87081-35-4]]

Produktübersicht

• Artikelname: Leptomycin B (Elactocin, Antibiotic ATS 1287B, Antibiotic CI 940, Antibiotic CL 1957A, Antibiotic PD 114720, Mantuamycin), CAS [[87081-35-4]]
• Artikelnummer: USB-L1671-38A
• Hersteller Artikelnummer: L1671-38A
• Alternativnummer: USB-L1671-38A-500
• Hersteller: US Biological
• Kategorie: Biochemikalien

Produktbeschreibung

Leptomycin B is the dominant and most studied member of the leptomycin class isolated from selected Streptomyces strains. Leptomycin B is a nanomolar active and specific nuclear export inhibitor. Its target is CRM1/exportin1 a protein in the nuclear export sequence (NES). Examples of proteins affected are c-Abl, cyclin B1, HIV-1 Rev, IkappaB, MPF, MAP/ERK, MDM2/p53, NF-kappaB/IkappaB7 and PKA. Export of many RNAs are also inhibited e.g. COX-2 and c-FOS mRNA. In addition Leptomycin B shows antifungal and antibacterial and potent antitumour activities. Solubility: Soluble in ethanol or methanol. Poor water solubility. Ethanol is recommended. Unstable in DMSO. Storage and Stability: Stable for 6 months after receipt at -20C. Related to: Anguinomycin A, Leptomycin A, Kazusamycin A, Kazusamycin B

Produkteigenschaften

• Molekulargewicht: 540.7
• Reinheit: ~99% by HPLC
• Formulierung: Colorless film
• CAS Nummer: [87081-35-4]