Lipin 2, Mouse Control Peptide (Lipin-2, LPIN2, KIAA0249)

Produktübersicht

• Artikelname: Lipin 2, Mouse Control Peptide (Lipin-2, LPIN2, KIAA0249)
• Artikelnummer: USB-L2497-10B
• Hersteller Artikelnummer: L2497-10B
• Alternativnummer: USB-L2497-10B-100
• Hersteller: US Biological
• Kategorie: Molekularbiologie
• Applikation: ELISA, WB

Produktbeschreibung

14aa peptide, Mouse Lipin-2 . The actions of insulin culminate in changes in the phosphorylation state of a number of downstream targets including phosphatidylinositol 3-OH kinase (PI3-kinase). Activation of PI3-kinase is central to insulin-stimulated phosphorylation in fat cells. In adipocytes, PI3 is involved in activation of protein kinase B (PKB), glycogen synthase, transitional regulators, 4E-BP1, p70s6k and mTOR protein (mammalian target of rapamycin). The kinase activity of mTOR functions in nutrient sensing pathway that maintains a proper balance of aa availability, protein synthesis and cell growth. Most importantly, mTOR controls the phosphorylation of a newly discovered protein Lipin-1, required for normal adipose tissue development and metabolism. The mutation in Lipin-1 gene results in immature adipocytes and thus in fatty liver dystrophy (fld) phenotype in mice and in lipodystrophy, a group of rare human diseases. These phenotypes are characterized by a triglyceride-filled fatty liver, loss of body fat, hypertrigyceridemia, insulin resistance, increased susceptibility to atherosclerosis, reduced fertility, reduced plasma Leptin and a progressive neuropathy affecting peripheral nerves in adulthood. Lipin defines a family of nuclear proteins containing at least three members in human and mouse: Lipin-1, Lipin-2 and Lipin-3. All Lipin members contain a nuclear signal seq, a highly conserved amino- (NLIP) and a carboxy-terminal (CLIP) domains. Lipin-2: The human and mouse LPIN-2 genes have been mapped at chromosomes 18p and 17, respectively. The Lipin-2 seqs from mouse and human are ~90% identical. The overall aa seq of mouse Lipin-2 (891aa) is ~48% identical to mouse Lipin-1(891aa) and Lipin-3 (848aa).

Produkteigenschaften

• Reinheit: Highly purified
• Formulierung: Supplied as a liquid in PBS, pH 7.2