| Fluorinated quinolone antibacterial. DNA gyrase antagonist. Lomefloxacin HCl is a hydrochloride salt of lomefloxacin and is a fluoroquinolone antibiotic.Lomefloxacin is an orally bioavailable, broad-spectrum fluoroquinolone antibiotic.1 In vitro, it inhibits growth of N. gonorrhoeae, E. coli, K. pneumoniae, P. vulgaris, S. epidermidis, and M. morganii (MIC90s = 0.1, 0.39, 0.39, 0.39, 0.39, and 0.78ug/ml, respectively). It also inhibits growth of S. aureus and methicillin-resistant S. aureus (MRSA, MIC90 = 3.13ug/ml for both) and of H. influenzae and ampicillin-resistant H. influenzae (MIC90 = 0.1ug/ml for both). In vivo, lomefloxacin inhibits the growth of P. mirabilis, E. coli, K. pneumoniae, and S. aureus (ED50s = 1.39, 1.45, 1.78, and 6.66mg/kg, respectively) in mouse models of systemic infection. It inhibits bacterial DNA gyrase, thereby inhibiting DNA synthesis and bacterial growth.2 Formulations containing lomefloxacin have been used in the treatment of bronchitis and urinary tract bacterial infections. Synonyms: 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid Hydrochloride, Alkaflox, Bareon, Chimono, Lomebact, Lomef 400, Lomflox, Lomitas, Lomoxin, Maxaquin, Mazaquin, NY 198, Orchacin, SC 47111, Uniquin CAS No: 98079-52-8 Free Base: 98079-51-7 Molecular Formula: C17H20ClF2N3O3 Molecular Weight: 387.81 Appearance: Crystalline solid Purity: 98% (HPLC) Melting Point: >275C(dec.) Solubility: Methanol (Slightly, Heated), Water (Slightly, Heated) Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. |
