| Cancer cell line apoptotic inducer via HMG-CoA reductase mechanism. Statin compound. Potent competitive HMG-CoA reductase inhibitor. Anti-hypercholesterolemic agent. Cholesterol/isoprenoid biosynthesis inhibitor. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. Inhibits the isoprenylation of Ras and Rho family GTPases. Causes cell cycle arrest in G1 and G2/M phases through modulation of proteasome in cancer cell lines. Smooth muscle cell proliferation inhibitor. Apoptosis inducer. Anticancer compound. Anti-adhesive, immunomodulatory and anti-inflammatory compound. Stimulates bone formation. Increases cellular resistance to anticancer agents such as doxorubicin and etoposide. Suppresses ICAM-1-LFA-1 interactions, which blocks virus replication and infection. Anti-hypertensive agent. Suppresses TNF-induced NF-kappaB activation. Modulates key cell signaling pathways, like Ras, MAPK and EGFR (modest). Synonyms: Mevinolin, 6a-Methylcompactin, Monakolin K, MK-803, 6-alpha-Methylcompactin, BRN 3631989 Source: Aspergillus sp. CAS Number: 75330-75-5 Molecular Formula: C24H36O5 Molecular Weight: 404.5 Purity: 98.5% Appearance: White crystalline powder Solubility: Soluble in DMSO and ethanol Loss on Drying: 0.1% Heavy Metals: 0.002% Specific Rotation: +324-338 Residue on Ignition: 0.2% Indentification (Infrared, UV): Conforms to reference Exceeds USP Specifications |
