LTBR, also known as Lymphotoxin beta Receptor and tumor necrosis factor receptor superfamily member 3 is a 47kD transmembrane protein containing 3 TNF receptor domains. The LTBR is a receptor for the heterotrimeric lymphotoxin complex (composed of LTa and LTB as well as light. LTBR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LTBR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LTBR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LTBR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. This antibody is an agonistic antibody for the LTBR capable of inducing apoptosis (with IFN-g treatment). Applications: Suitable for use in Induction of apoptosis, ELISA, Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilutions: Flow Cytometry: 0.5ug/10e5 cells in 100ul. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Klonalität:
Monoclonal
Klon-Bezeichnung:
[31G4D8]
Reinheit:
Purified by affinity chromatography.
Formulierung:
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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