Macrophage Derived Chemokine, Recombinant, Human (MDC, CCL22, STCP-1, ABCD-1)
Artikelnummer:
USB-M1201-51H
Hersteller Artikelnummer:
M1201-51H
Alternativnummer:
USB-M1201-51H-20
Hersteller:
US Biological
Kategorie:
Molekularbiologie
MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells, and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant human MDC is an 8kD protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Recombinant corresponding to 67aa from human MDC expressed in E. coli. Molecular Weight: ~8kD Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10-100ng/ml. Amino Acid Sequence: YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ Storage and Stability: Lyophilized and reconstituted products are stable for 6 months after receipt at -20C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplied as a lyophilized powder. Reconstitute with with sterile ddH2O, 0.1% HSA or BSA to 0.1-1mg/ml. Further dilutions can be made into other buffered solutions.
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