MS-275 is a synthetic benzamide derivative that inhibited partially purified human histone deacetylase (HDA) with an IC50 of 2uM and induced hyperacetylation of nuclear histones in tumor cell lines. MS-275 inhibited the proliferation of various human tumor cell lines such as A2780, Calu-3, HL-60, and K562 (IC50 values were 0.0415uM, 0.195uM, 0.212uM, and 0.589uM, respectively). MS-275 also inhibited the growth of human tumor xenografts in nude mouse. Synonyms: Carbamic acid, ((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3- pyridinylmethyl ester, Histone Deacetylase Inhibitor, SNDX-275, HDAC1/HDAC3 inhibitor, N-[[4-[[(2-Aminophenyl)amino]carbonyl]phenyl]methyl]carbamic Acid 3-Pyridinylmethyl Ester, (Pyridin -3-yl)methyl 4-(2-Aminophenylcarbamoyl)benzylcarbamate, MS 27-275, MS 275, MS 275-27, N-(2- Aminophenyl)-4-[N-(pyridine-3-yl-methoxycarbonyl)- CAS No: 209783-80-2 Molecular Weight: 376.41 Molecular Formula: C21H20N4O3 Appearance: Light yellow to light beige solid Purity: 95% (HPLC) NMR, MS: Conforms to reference Melting Point: 157-158.5C Solubility: Soluble in DMSO at 25mg/ml with slight warming, very poorly soluble in ethanol and water, maximum solubility in plain water is estimated to be about 10-20uM. buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at 4C. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molekulargewicht:
376.41
Reinheit:
95% (HPLC)
Formulierung:
Light yellow to light beige solid
CAS Nummer:
[209783-80-2]
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