Inhibitor of bacterial DNA synthesis. Nalidixic acid is the first of the synthetic quinolone antibiotics. It is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains two nitrogen atoms, unlike quinoline, which has a single nitrogen atom.[1] Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the 1960s.[1] Used clinically from 1967.[1] Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts in a bacteriostatic manner, that is, it inhibits growth and reproduction. In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth. Synonyms: 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicAcid, 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic Acid, Betaxina, Cybis, Dixiben, Eucistin, NegGram, Nelidix, Win 18320, Wintomylon CAS No: 389-08-2 Molecular Formula: C12H12N2O3 Molecular Weight: 232.24 Purity (1H-NMR): 98% Appearance: White to yellow powder FT-IR: Conforms to reference Melting Point: 230-231C (lit) Storage and Stability: Store at RT. Stable for 12 months after receipt.
Molekulargewicht:
232.24
CAS Nummer:
[389-08-2]
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