Nectin 2 (Poliovirus Receptor-related Protein 2, PRR2), IgG2a, Clone: [6A606 502-57], Rat, Monoclonal

Produktübersicht

• Artikelname: Nectin 2 (Poliovirus Receptor-related Protein 2, PRR2), IgG2a, Clone: [6A606 502-57], Rat, Monoclonal
• Artikelnummer: USB-N0571-50
• Hersteller Artikelnummer: N0571-50
• Alternativnummer: USB-N0571-50-100
• Hersteller: US Biological
• Wirt: Rat
• Kategorie: Antikörper
• Applikation: FC, IHC, IP, WB
• Immunogen: Raised against the extracellular domain of mouse Nectin 2

Produktbeschreibung

Nectin (originally isolated as poliovirus receptor-related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is colocalized with afadin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. The nectin family consist of Nectin 1, Nectin 2 and Nectin 3. Nectin 2 also known as PRR2 or CD112 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cell lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse Nectin 2 leads to infertility of male mice. Applications: Suitable for use in Western Blot, Immunoprecipitation, Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:10 Flow Cytometry: 1:10 Immunohistochemistry (Frozen): 1:10, Fixation with PFA or acetone/methanol is recommended. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Produkteigenschaften

• Klonalität: Monoclonal
• Klon-Bezeichnung: [6A606 502-57]
• Isotyp: IgG2a
• Reinheit: Purified by Protein G affinity chromatography.
• Formulierung: Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.