| Nucleohistone is a sodium-containing complex of histone and DNA. DNA is combined, as nucleohistone, with histone proteins in the chromosomes and nuclei of all cells except bacteria. It has been suggested that histones are involved in regulating gene function. The molecular structure of nucleohistone is basic to the structure of chromosomes. X-ray diffraction, and physical chemistry studies, suggest a coiled molecular structure for nucleohistone which is compatible with results from electron microscopy. Solubility: Soluble in PBS, pH 7.1 or ddH20 when pH is neutral. Storage and Stability: Lyophilized and reconstituted products may be stored at -20C. Stable for 12 months after receipt at -20C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
